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Phosphatidylserine (PS) is directly or indirectly implicated in practically every cell membrane from the brain and nervous system to hormone function and the adrenal glands. Although an exhaustive list of possible applications for the phospholipid is not included, the following are the primary scientifically backed reasons why anyone – from children to post graduate doctoral candidates – should add PS from iStressedOut to their mental health, wellness and preventing dementia.

  1. Over a long time period (11.5 years), cognitive decline occurred in all age groups.[i]

  1. Lifetime stressors trigger and facilitate the leap from mild cognitive impairment to full blown dementia. One factor increasingly implicated in chronic stress that could be driven by a big change, usually negative like prolonged illness, injury or a major operation. [ii]

  1.  Women who had been through significant stressors in mid-life had a 65% greater risk of developing dementia later in life. Stressful events can trigger a cascade of reactions involving the stress hormones and eventually leading to atrophy in the brain’s area of memory  and known to be most affected by Alzheimer’s disease.[iii]

  1. More than 35 clinical trials with PS indicate taking PS daily can relieve, improve and reverse age-related declines in memory, learning, concentration and mood.

  1. PS treatment (2 iStressedOut/day for 3 months) on elderly people with AAMI improved their visual memory.[iv]

  1.  PS (2 iStressedOut/day for 12 weeks) was effective in improving memory functions, such as memorizing names and faces, of elderly people with AAMI.[v]

  1. PS was most effective in memorizing faces.[vi]

  1. Seventy-eight elderly people with mild cognitive impairment (50-69 years old) were given PS (1 iStressedOut/day) for 6 months. Their memory scores were significantly increased.[vii]

  1. The memory improvements from taking PS resulted in improved verbal recall, and increased memory ability in the earliest stage of dementia. [viii]

  1. PS is considered as safe ingredient and 6 months of PS supplementation could improve the memory functions of the elderly with memory complaints.[ix]

  1. PS for 6 months improved memory function, especially delayed recall, in the elderly with memory complaints.[x]

  1. Long term supplementation of PS significantly decreases specific brain waves in right frontal brain regions (these areas are normally increased when you are under stress) before and after stress. The results for brain wave power in the PS group were connected to a more relaxed state.[xi]

  1. Diets are deficient in PS and Modern industrial food production of fats and oils decreases all of the natural phospholipids including phosphatidylserine.[xii]

PS is an essential brain and memory supplement for

any one over age 40 or with a family.

Chew 1 iStressedOut tab 3 times a day.

Scientific Validation

[i] Am J Psychiatry 1999;156:58-65

[ii] Stress Linked to Alzheimer’s, published 25 June 2012. Source http://alzheimers.org.uk/site/scripts/news_article.php?newsID=1243

[iii] Johansson L, Guo X, Waern M et al. Midlife Pyschological Stress and Risk of Dementia: a 35-year Longitudinal Population Study. Brain, Journal of Neurology. Vol 133 No 8. Pp. 2217-2224.

[iv] Gindin J., Novikov M., Dedar D., Walter-Ginzburg A., Naor S., Levi S. The effect of plant phosphatidylserine of age—associated memory impairment and mood in the functioning elderly. The Geriatric Institute for Education and Research, and Department Geriatrics, Kapran Hospital. Rehovot; Israel: 1995.

[v] Crook T.H. In: Treatment of age-related cognitive decline: effects of phosphatidylserine, in Anti-Aging Medical Therapeutics. Vol. II. Katz R.M., Goldman R., editors. Health Quest Publications; Marina del Rey, Carfornia: 1998. pp. 20–28.

[vi] Schreiber S., Kampf-Sherf O., Gorfine M., Kelly D., Oppenheim Y., Lerer B. An open trial of plant-source derived phosphatidylserine for treatment of age-related cognitive decline. Isr. J. Psychiatr. Relat. Sci. 2000;37:302–307.

[vii] Kato-Kataoka A, Sakai M, Ebina R, Nonaka C, Asano T, Miyamori T.    Soybean-derived phosphatidylserine improves memory function of the elderly Japanese subjects with memory complaints. J Clin Biochem Nutr. 2010 Nov;47(3):246-55. doi: 10.3164/jcbn.10-62. Epub 2010 Sep 29.  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2966935/

[viii] Ibid.

[ix] Ibid.

[x] Ibid.

[xi] Baumeister J, Barthel T, Geiss KR, Weiss M. Influence of phosphatidylserine on cognitive performance and cortical activity after induced stress. Nutr Neurosci. 2008 Jun;11(3):103-10

[xii] M. Hamm. Ernährungswissenschaftliche Stellungnahme zur Veränderung der nutritiven Versorgung mit Phosphatidylserin (PS), 2002.

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