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Phosphatidylserine (PS) is present in every cell membrane from the brain and nervous system to hormone function and the adrenal glands. Here are the primary scientifically backed reasons why anyone – from professional athletes to weekend warriors should add PS from iStressedOut to their health, wellness and recovery regimen.

  1. Reduces the tissue breakdown that accompanies overtraining and / or overstretching.[i]  PS reduces  muscle soreness after exercise.[ii]

  1. Intensely trained athletes found that 800 mg of PS taken daily reduced the cortisol rise by 20% as compared with placebo.[iii] 

  1. Cyclists who took PS found that they could relieve overtraining symptoms, including muscle soreness. [iv] [v] [vi] 

  1. PS improves exercise capacity during high intensity training and will increase performance during intermittent running.[vii] 

  1. Nonathletic males found that daily doses of 400 and 800 mg of PS reduced cortisol levels after exercise by 16% and 30%.[viii]  

  1.  PS relieves overtraining symptoms, including muscle soreness due to cortisol.[ix] [x] [xi] [xii] [xiii] 

  1. PS helps insomnia and sleep disorders caused by excess cortisol at the end of the day. [xiv] 

  1.  PS raises lowT by increasing the testosterone cortisol ratio. [xv] 

PS is an essential sports recovery supplement for

the serious professional athlete and

athletes of all ages and ability.

Chewing 2 iStressedOut tabs after every workout is

the essential recovery advantage!

Scientific Validation


[i] Starks MA, Starks SL, Kingsley M, Purpura M, Jäger R (7 2008). "The effects of phosphatidylserine on endocrine response to moderate intensity exercise". Journal of the International Society of Sports Nutrition 5: 11.doi:10.1186/1550-2783-5-11. PMC 2503954. PMID 18662395

[ii] Jäger R, Purpura M, and Kingsley M. Phospholipids and sports performance. J Int Soc Sports Nutr. 2007;4:5. doi: 10.1186/1550-2783-4-5

[iii] Hirayama S, Masuda Y, Rabeler R. 2006, September/October. Effect of phosphatidylserine administration on symptoms of attention-deficit/hyperactivity disorder in children. Agro Food; 17(5): 32–36. url=http://www.lipamin-ps.com/upd/file/agro_16_20.pdf

[iv]Monteleone P, Maj M, Beinat L, et al. Blunting by chronic phosphatidylserine administration of the stress-induced activation of the hypothalamo-pituitary-adrenal axis in healthy men. Eur J Clin Pharmacol . 1992;42:385-388.

[v] Fahey TD, Pearl M. The hormonal and perceptive effects of phosphatidylserine administration during two weeks of resistive exercise-induced overtraining. Biol Sport. 1998;15:135-144.

[vi] Monteleone P, Beinat L, Tanzillo C, et al. Effects of phosphatidylserine on the neuroendocrine response to physical stress in humans. Neuroendocrinology. 1990;52:243-248.

[vii] Ibid.

[viii] Monteleone P, Maj M, Beinat L, et al. Blunting by chronic phosphatidylserine administration of the stress-induced activation of the hypothalamo-pituitary-adrenal axis in healthy men. Eur J Clin Pharmacol . 1992;42:385-388.

[ix] Monteleone P, Maj M, Beinat L, et al. Blunting by chronic phosphatidylserine administration of the stress-induced activation of the hypothalamo-pituitary-adrenal axis in healthy men. Eur J Clin Pharmacol . 1992;42:385-388.

[x] Fahey TD, Pearl M. The hormonal and perceptive effects of phosphatidylserine administration during two weeks of resistive exercise-induced overtraining. Biol Sport. 1998;15:135-144.

[xi] Monteleone P, Beinat L, Tanzillo C, et al. Effects of phosphatidylserine on the neuroendocrine response to physical stress in humans. Neuroendocrinology. 1990;52:243-248.

[xii] Kingsley MI, Miller M, Kilduff LP, et al. Effects of phosphatidylserine on exercise capacity during cycling in active males. Med Sci Sports Exerc . 2006;38:64-71.

[xiii] Hirayama S, Masuda Y, Rabeler R. 2006, September/October. Effect of phosphatidylserine administration on symptoms of attention-deficit/hyperactivity disorder in children. Agro Food; 17(5): 32–36. url=http://www.lipamin-ps.com/upd/file/agro_16_20.pdf

[xiv] Journal of Clinical Endocrinology & Metabolism August 2001; 86:3787-3794

[xv] Starks MA, Starks SL, Kingsley M, Purpura M, Jäger R.The effects of phosphatidylserine on endocrine response to moderate intensity exercise. J Int Soc Sports Nutr. 2008 Jul 28;5:11. doi: 10.1186/1550-2783-5-11.

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